About Romiplostim

Commercially known as Nplate, Romiplostim is known as a peptibody and comes in liquid form and is delivered through regular (usually weekly) subcutaneous injections. This treatment is only available on the PBS to patients who relapse following splenectomy or have contraindications to splenectomy and previously treatment failure.

Treatment usually commences at a low dose and is adjusted depending on the results.

This form of treatment is not recommended for women who are or plan to become pregnant or while breast-feeding.

Side effects# are usually mild but may include:

  • headache
  • joint or muscle pain
  • pain in the arms, legs, or shoulders
  • numbness, burning, or tingling in the arms or legs
  • stomach pain
  • heartburn
  • difficulty falling asleep or staying asleep

If you experience any of the following symptoms, we encourage you to contact your medical professional immediately:

  • swelling, pain, tenderness, warmth or redness in one leg
  • shortness of breath
  • coughing up blood
  • fast heartbeat
  • fast breathing
  • pain when breathing deeply
  • pain in the chest, arms, back, neck, jaw, or stomach
  • breaking out in a cold sweat
  • nausea
  • lightheadedness
  • slow or difficult speech
  • dizziness or faintness
  • weakness or numbness of an arm or leg


# These side effects were reported by patients on the initial trials. Many of them are likely to be steroid withdrawal effects and most people have either no or minimal side effects from TPORAs. The rate of people stopping these treatments due to side effects is very low.


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